Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure
Joint Authors
Van Craenenbroeck, Emeline M.
Van Ackeren, Katrijn
Hoymans, Vicky Y.
Roeykens, Johan
Verpooten, Gert A.
Vrints, Christiaan J.
Couttenye, Marie M.
Van Craenenbroeck, Amaryllis H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Monocytes (Mon1-2-3) play a substantial role in low-grade inflammation associated with high cardiovascular morbidity and mortality of patients with chronic kidney disease (CKD) and chronic heart failure (CHF).
The effect of an acute exercise bout on monocyte subsets in the setting of systemic inflammation is currently unknown.
This study aims (1) to evaluate baseline distribution of monocyte subsets in CHF and CKD versus healthy subjects (HS) and (2) to evaluate the effect of an acute exercise bout.
Exercise-induced IL-6 and MCP-1 release are related to the Mon1-2-3 response.
Methods.
Twenty CHF patients, 20 CKD patients, and 15 HS were included.
Before and after a maximal cardiopulmonary exercise test, monocyte subsets were quantified by flow cytometry: CD14++CD16−CCR2+ (Mon1), CD14++CD16+CCR2+ (Mon2), and CD14+CD16++CCR2− (Mon3).
Serum levels of IL-6 and MCP-1 were determined by ELISA.
Results.
Baseline distribution of Mon1-2-3 was comparable between the 3 groups.
Following acute exercise, %Mon2 and %Mon3 increased significantly at the expense of a decrease in %Mon1 in HS and in CKD.
This response was significantly attenuated in CHF (P<0.05).
In HS only, MCP-1 levels increased following exercise; IL-6 levels were unchanged.
Circulatory power was a strong and independent predictor of the changes in Mon1 (β=-0.461, P<0.001) and Mon3 (β=0.449, P<0.001); and baseline LVEF of the change in Mon2 (β=0.441, P<0.001).
Conclusion.
The response of monocytes to acute exercise is characterized by an increase in proangiogenic and proinflammatory Mon2 and Mon3 at the expense of phagocytic Mon1.
This exercise-induced monocyte subset response is mainly driven by hemodynamic changes and not by preexistent low-grade inflammation.
American Psychological Association (APA)
Van Craenenbroeck, Amaryllis H.& Van Ackeren, Katrijn& Hoymans, Vicky Y.& Roeykens, Johan& Verpooten, Gert A.& Vrints, Christiaan J.…[et al.]. 2014. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
Modern Language Association (MLA)
Van Craenenbroeck, Amaryllis H.…[et al.]. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
American Medical Association (AMA)
Van Craenenbroeck, Amaryllis H.& Van Ackeren, Katrijn& Hoymans, Vicky Y.& Roeykens, Johan& Verpooten, Gert A.& Vrints, Christiaan J.…[et al.]. Acute Exercise-Induced Response of Monocyte Subtypes in Chronic Heart and Renal Failure. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043390