Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

Joint Authors

Sun, Shaomei
Wu, Hongmei
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Du, Huanmin
Liu, Li
Jia, Qiyu
Wang, Xing
Song, Kun
Niu, Kaijun

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-29

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS).

We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS.

Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre.

Both a baseline cross-sectional (n=46,179) and a prospective assessment (n=13,061) were performed.

Participants without a history of MS were followed up for 5 years.

Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up.

Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS.

The subnormal leukocyte counts group (1,100–3,900 cells/mm3) had the lowest prevalence and incidence of MS.

The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (both P for trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders.

This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS.

The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.

American Psychological Association (APA)

Sun, Shaomei& Wu, Hongmei& Zhang, Qing& Wang, Chongjin& Guo, Yinting& Du, Huanmin…[et al.]. 2014. Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043544

Modern Language Association (MLA)

Sun, Shaomei…[et al.]. Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043544

American Medical Association (AMA)

Sun, Shaomei& Wu, Hongmei& Zhang, Qing& Wang, Chongjin& Guo, Yinting& Du, Huanmin…[et al.]. Subnormal Peripheral Blood Leukocyte Counts Are Related to the Lowest Prevalence and Incidence of Metabolic Syndrome: Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043544

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043544