![](/images/graphics-bg.png)
Abnormal Cytokine Profile in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome and Erectile Dysfunction
Joint Authors
Siafakas, Nikolaos M.
Bouloukaki, Izolde
Papadimitriou, Vaios
Sofras, Frank
Mermigkis, Charalampos
Moniaki, Violeta
Schiza, Sophia E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) show a high prevalence of erectile dysfunction (ED).
Although the underlying pathogenesis is still unknown, endothelial dysfunction, induced by inflammatory cytokines, chemokines, and adhesion molecules, has been proposed as a possible mechanism.
The aim of this study was to assess whether OSAHS is associated with activation of the inflammatory cytokine system in patients with ED compared to the matched OSAHS patients with normal sexual function.
Thirty-one patients with severe OSAHS and ED were included.
Fifteen patients with severe OSAHS and without ED served as controls.
Serum concentrations of high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-a), interleukin-6 (IL-6), interleukin-8 (IL-8), and adiponectin were measured after the diagnostic polysomnography.
We found that hsCRP levels were significantly elevated in OSAHS patients with ED compared to controls.
Similarly, TNF-a levels, IL-6, and IL-8 were elevated in OSAHS patients with ED compared to controls.
Serum adiponectin levels were lower in OSAHS-ED patients, but the difference did not reach statistical significance.
The presence of ED in patients with severe OSAHS is associated with elevated levels of inflammatory markers, underlining a possible involvement of endothelial dysfunction in the pathogenesis of ED.
American Psychological Association (APA)
Bouloukaki, Izolde& Papadimitriou, Vaios& Sofras, Frank& Mermigkis, Charalampos& Moniaki, Violeta& Siafakas, Nikolaos M.…[et al.]. 2014. Abnormal Cytokine Profile in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome and Erectile Dysfunction. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043645
Modern Language Association (MLA)
Bouloukaki, Izolde…[et al.]. Abnormal Cytokine Profile in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome and Erectile Dysfunction. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043645
American Medical Association (AMA)
Bouloukaki, Izolde& Papadimitriou, Vaios& Sofras, Frank& Mermigkis, Charalampos& Moniaki, Violeta& Siafakas, Nikolaos M.…[et al.]. Abnormal Cytokine Profile in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome and Erectile Dysfunction. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043645