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Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults
Joint Authors
Cheng, Shih-Ping
Liu, Chien-Liang
Liu, Tsang-Pai
Hsu, Yi-Chiung
Lee, Jie-Jen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
High levels of parathyroid hormone (PTH) appear to be associated with an increased mortality.
Previous studies concerning the relationship of inflammatory markers with hyperparathyroidism have yielded inconsistent results.
This study investigated whether serum PTH concentrations were independently associated with several inflammatory markers among the US adults.
Materials and Methods.
Using data from the National Health and Nutrition Examination Survey, we examined the relation between serum PTH and C-reactive protein (CRP), red cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) levels with weighted linear regression.
Additionally, we examined the relation with increased modified Glasgow Prognostic Score (mGPS) by using weighted logistic regression.
Results.
CRP, RDW, and PLR values increased with increasing serum PTH concentration.
After extensively adjusting for covariates, CRP and RDW increased linearly and across PTH categories (all P < 0.001 ), while PLR marginally increased ( P = 0.190 and P = 0.095 using PTH as a categorical and continuous variable, resp.).
The odds ratio of increased mGPS was 1.11 and 1.31 across PTH categories and with increasing PTH levels continuously.
Conclusion.
These nationally representative data indicate that serum PTH levels are independently associated with several inflammatory markers in the US population.
The casual relationship between PTH levels and inflammation remains to be elucidated.
American Psychological Association (APA)
Cheng, Shih-Ping& Liu, Chien-Liang& Liu, Tsang-Pai& Hsu, Yi-Chiung& Lee, Jie-Jen. 2014. Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043747
Modern Language Association (MLA)
Cheng, Shih-Ping…[et al.]. Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043747
American Medical Association (AMA)
Cheng, Shih-Ping& Liu, Chien-Liang& Liu, Tsang-Pai& Hsu, Yi-Chiung& Lee, Jie-Jen. Association between Parathyroid Hormone Levels and Inflammatory Markers among US Adults. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043747