Splenic Stromal Cells from Aged Mice Produce Higher Levels ofIL-6 Compared to Young Mice
Joint Authors
Park, Jihyun
Miyakawa, Takuya
Shiokawa, Aya
Nakajima-Adachi, Haruyo
Tanokura, Masaru
Hachimura, Satoshi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflamm-aging indicates the chronic inflammatory state resulting from increased secretion of proinflammatory cytokines and mediators such as IL-6 in the elderly.
Our principle objective was to identify cell types that were affected with aging concerning IL-6 secretion in the murine model.
We compared IL-6 production in spleen cells from both young and aged mice and isolated several types of cells from spleen and investigated IL-6 mRNA expression and protein production.
IL-6 protein productions in cultured stromal cells from aged mice spleen were significantly high compared to young mice upon LPS stimulation.
IL-6 mRNA expression level of freshly isolated stromal cells from aged mice was high compared to young mice.
Furthermore, stromal cells of aged mice highly expressed IL-6 mRNA after LPS injection in vivo.
These results suggest that stromal cells play a role in producing IL-6 in aged mice and imply that they contribute to the chronic inflammatory condition in the elderly.
American Psychological Association (APA)
Park, Jihyun& Miyakawa, Takuya& Shiokawa, Aya& Nakajima-Adachi, Haruyo& Tanokura, Masaru& Hachimura, Satoshi. 2014. Splenic Stromal Cells from Aged Mice Produce Higher Levels ofIL-6 Compared to Young Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043833
Modern Language Association (MLA)
Park, Jihyun…[et al.]. Splenic Stromal Cells from Aged Mice Produce Higher Levels ofIL-6 Compared to Young Mice. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043833
American Medical Association (AMA)
Park, Jihyun& Miyakawa, Takuya& Shiokawa, Aya& Nakajima-Adachi, Haruyo& Tanokura, Masaru& Hachimura, Satoshi. Splenic Stromal Cells from Aged Mice Produce Higher Levels ofIL-6 Compared to Young Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043833
