Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome
Joint Authors
Dominguez-Rodriguez, Alberto
Abreu-Gonzalez, Pedro
Hernandez-Baldomero, Idaira F.
Bosa-Ojeda, Francisco
Avanzas, Pablo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Among the numerous emerging biomarkers, high-sensitivity C-reactive protein (hsCRP) and growth-differentiation factor-15 (GDF-15) have received widespread interest, with their potential role as predictors of cardiovascular risk.
The concentrations of inflammatory biomarkers, however, are influenced, among others, by physiological variations, which are the natural, within-individual variation occurring over time.
The aims of our study are: (a) to describe the changes in hsCRP and GDF-15 levels over a period of time and after an episode of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and (b) to examine whether the rate of change in hsCRP and GDF-15 after the acute event is associated with long-term major cardiovascular adverse events (MACE).
Two hundred and Fifty five NSTE-ACS patients were included in the study.
We measured hsCRP and GDF-15 concentrations, at admission and again 36 months after admission (end of the follow-up period).
The present study shows that the change of hsCRP levels, measured after 36 months, does not predict MACE in NSTEACS-patients.
However, the level of GDF-15 measured, after 36 months, was a stronger predictor of MACE, in comparison to the acute unstable phase.
American Psychological Association (APA)
Dominguez-Rodriguez, Alberto& Abreu-Gonzalez, Pedro& Hernandez-Baldomero, Idaira F.& Avanzas, Pablo& Bosa-Ojeda, Francisco. 2014. Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043902
Modern Language Association (MLA)
Dominguez-Rodriguez, Alberto…[et al.]. Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043902
American Medical Association (AMA)
Dominguez-Rodriguez, Alberto& Abreu-Gonzalez, Pedro& Hernandez-Baldomero, Idaira F.& Avanzas, Pablo& Bosa-Ojeda, Francisco. Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043902