![](/images/graphics-bg.png)
Symptoms and Association with Health Outcomes in Relapsing-Remitting Multiple Sclerosis: Results of a US Patient Survey
Joint Authors
Vietri, Jeffrey
Williams, Angela E.
Isherwood, Gina
Flor, Armando
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
A variety of symptoms have been reported, but the prevalence of specific symptoms in relapsing-remitting multiple sclerosis (RRMS), how they are related to one another, and their impact on patient reported outcomes is not well understood.
Objective.
To describe how symptoms of RRMS cooccur and their impact on patient-reported outcomes.
Methods.
Individuals who reported a physician diagnosis of RRMS in a large general health survey in the United States indicated the symptoms they experience because of RRMS and completed validated scales, including the work productivity and activity impairment questionnaire and either the SF-12v2 or SF-36v2.
Symptom clusters were identified through hierarchical cluster analysis, and the relationship between clusters and outcomes was assessed through regression.
Results.
Fatigue, difficulty walking, and numbness were the most commonly reported symptoms.
Seven symptom clusters were identified, and several were significantly related to patient reported outcomes.
Pain, muscle spasms, and stiffness formed a cluster strongly related to physical quality of life; depression was strongly related to mental quality of life and cognitive difficulty was associated with work impairment.
Conclusions.
Symptoms in RRMS show a strong relationship with quality of life and should be taken into consideration in treatment decisions and evaluation of treatment success.
American Psychological Association (APA)
Williams, Angela E.& Vietri, Jeffrey& Isherwood, Gina& Flor, Armando. 2014. Symptoms and Association with Health Outcomes in Relapsing-Remitting Multiple Sclerosis: Results of a US Patient Survey. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046594
Modern Language Association (MLA)
Williams, Angela E.…[et al.]. Symptoms and Association with Health Outcomes in Relapsing-Remitting Multiple Sclerosis: Results of a US Patient Survey. Multiple Sclerosis International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046594
American Medical Association (AMA)
Williams, Angela E.& Vietri, Jeffrey& Isherwood, Gina& Flor, Armando. Symptoms and Association with Health Outcomes in Relapsing-Remitting Multiple Sclerosis: Results of a US Patient Survey. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046594