Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study
Joint Authors
Hansen, Dominique
Wens, Inez
Eijnde, Bert O.
Feys, Peter
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
Walking capacity is reduced in subjects with multiple sclerosis (MS).
To develop effective exercise interventions to enhance walking capacity, it is important to determine the impact of factors, modifiable by exercise intervention (maximal muscle strength versus muscle oxidative capacity), on walking capacity.
The purpose of this pilot study is to discriminate between the impact of maximal muscle strength versus muscle oxidative capacity on walking capacity in subjects with MS.
Methods.
From 24 patients with MS, muscle oxidative capacity was determined by calculation of exercise-onset oxygen uptake kinetics (mean response time) during submaximal exercise bouts.
Maximal muscle strength (isometric knee extension and flexion peak torque) was assessed on dynamometer.
All subjects completed a 6-minute walking test.
Relationships between walking capacity (as a percentage of normal value) and muscle strength (of knee flexors and extensors) versus muscle oxidative capacity were assessed in multivariate regression analyses.
Results.
The expanded disability status score (EDSS) showed a significant univariate correlation ( r = - 0.70 , P < 0.004 ) with walking capacity.
In multivariate regression analyses, EDSS and mean response time, but not muscle strength, were independently related to walking capacity ( P < 0.05 ).
Conclusions.
Walking distance is, next to disability level and not taking neurologic symptoms/deficits into account, primarily related to muscle oxidative capacity in subjects with MS.
Additional study is needed to further examine/verify these findings.
American Psychological Association (APA)
Hansen, Dominique& Feys, Peter& Wens, Inez& Eijnde, Bert O.. 2014. Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046613
Modern Language Association (MLA)
Hansen, Dominique…[et al.]. Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study. Multiple Sclerosis International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046613
American Medical Association (AMA)
Hansen, Dominique& Feys, Peter& Wens, Inez& Eijnde, Bert O.. Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046613