Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics
Joint Authors
Kokot, Teresa
Dzięgielewska-Gęsiak, Sylwia
Wysocka, Ewa
Michalak, Sławomir
Nowakowska-Zajdel, Ewa
Muc-Wierzgoń, Małgorzata
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation.
Methods.
52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure.
During an oral glucose tolerance test (OGTT) fasting (0′) and 120-minute (120′) glycemia and insulinemia were determined, and type 2 diabetics (n=6) were excluded.
Subjects were tested for glycated hemoglobin HbA1c, plasma lipids, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of erythrocyte superoxide dismutase (SOD-1).
According to OGTT results, patients were classified as normoglycemics, (NGT, n=18) and prediabetics, (PRE, n=28).
Results.
Both groups did not differ with their lipids, FAT, and TBARS.
PRE group had higher WC (P<0.002) and BMI (P<0.002).
Lower SOD-1 activity (P<0.04) and TAS status (P<0.04) were found in PRE versus NGT group.
Significance.
In elderly prediabetics, SOD-1 and TAS seem to reflect the first symptoms of oxidative stress, while TBARS are later biomarkers of oxidative stress.
American Psychological Association (APA)
Dzięgielewska-Gęsiak, Sylwia& Wysocka, Ewa& Michalak, Sławomir& Nowakowska-Zajdel, Ewa& Kokot, Teresa& Muc-Wierzgoń, Małgorzata. 2014. Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047176
Modern Language Association (MLA)
Dzięgielewska-Gęsiak, Sylwia…[et al.]. Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047176
American Medical Association (AMA)
Dzięgielewska-Gęsiak, Sylwia& Wysocka, Ewa& Michalak, Sławomir& Nowakowska-Zajdel, Ewa& Kokot, Teresa& Muc-Wierzgoń, Małgorzata. Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047176