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Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
Joint Authors
Waqif-Husain, S.
Mehdinia, Ali
Khoeini Sharifabadi, Malihe
Saber Tehrani, Mohammad
Aberoomand Azar, Parviz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe3O4 magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed.
For this purpose, the surface of MNP s was modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant.
Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized.
Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector.
The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83% ( n = 6 ) for 50 ng/mL.
The calibration curves obtained for studied drugs show reasonable linearity ( R 2 > 0.99 ) and the limit of detection (LOD s ) ranged between 2 and 7 ng/mL.
Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples.
American Psychological Association (APA)
Khoeini Sharifabadi, Malihe& Saber Tehrani, Mohammad& Waqif-Husain, S.& Mehdinia, Ali& Aberoomand Azar, Parviz. 2014. Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048387
Modern Language Association (MLA)
Khoeini Sharifabadi, Malihe…[et al.]. Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1048387
American Medical Association (AMA)
Khoeini Sharifabadi, Malihe& Saber Tehrani, Mohammad& Waqif-Husain, S.& Mehdinia, Ali& Aberoomand Azar, Parviz. Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1048387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048387