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Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
Joint Authors
Palomba, S.
Orio, Francesco
Muscogiuri, Giovanna
Serio, Bianca
Sessa, Mariarosaria
Giudice, Valentina
Ferrara, Idalucia
Tauchmanovà, Libuse
Colao, Annamaria
Selleri, Carmine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT).
This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management.
Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men.
Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively.
Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT.
Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment.
Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT.
American Psychological Association (APA)
Orio, Francesco& Muscogiuri, Giovanna& Palomba, S.& Serio, Bianca& Sessa, Mariarosaria& Giudice, Valentina…[et al.]. 2014. Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1049060
Modern Language Association (MLA)
Orio, Francesco…[et al.]. Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells. The Scientific World Journal No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1049060
American Medical Association (AMA)
Orio, Francesco& Muscogiuri, Giovanna& Palomba, S.& Serio, Bianca& Sessa, Mariarosaria& Giudice, Valentina…[et al.]. Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1049060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049060