Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method
Joint Authors
Wang, Dong
Song, Xixiao
Wang, Yan
Li, Xia
Jia, Shanshan
Wang, Zhijing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
Epilepsy is a common chronic neurological disorder.
We aim to investigate the underlying mechanism of epilepsy with partial least squares- (PLS-) based gene expression analysis, which is more sensitive than routine variance/regression analysis.
Methods.
Two microarray data sets were downloaded from the Gene Expression Omnibus (GEO) database.
PLS analysis was used to identify differentially expressed genes.
Gene ontology and network analysis were also implemented.
Results.
A total of 752 genes were identified to be differentially expressed, including 575 depressed and 177 overexpressed genes in patients.
For GO enrichment analysis, except for processes related to the nervous system, we also identified overrepresentation of dysregulated genes in angiogenesis.
Network analysis revealed two hub genes, CUL3 and EP300, which may serve as potential targets in further therapeutic studies.
Conclusion.
Our results here may provide new understanding for the underlying mechanisms of epilepsy pathogenesis and will offer potential targets for producing new treatments.
American Psychological Association (APA)
Wang, Dong& Song, Xixiao& Wang, Yan& Li, Xia& Jia, Shanshan& Wang, Zhijing. 2014. Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1050815
Modern Language Association (MLA)
Wang, Dong…[et al.]. Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method. The Scientific World Journal No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1050815
American Medical Association (AMA)
Wang, Dong& Song, Xixiao& Wang, Yan& Li, Xia& Jia, Shanshan& Wang, Zhijing. Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1050815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050815