Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility
Joint Authors
Komiya, A.
Kawauchi, Yoko
Kato, Tomonori
Watanabe, Akihiko
Fuse, Hideki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
The clinical factors associated with sperm DNA fragmentation (SDF) were investigated in male patients with infertility.
Materials and Methods.
Fifty-four ejaculates from infertile Japanese males were used.
Thirty-three and twenty-one were from the patients with varicoceles and idiopathic causes of infertility, respectively.
We performed blood tests, including the serum sex hormone levels, and conventional and computer-assisted semen analyses.
The sperm nuclear vacuolization (SNV) was evaluated using a high-magnification microscope.
The SDF was evaluated using the sperm chromatin dispersion test (SCDt) to determine the SDF index (SDFI).
The SDFI was compared with semen parameters and other clinical variables, including lifestyle factors.
Results.
The SDFI was 41.3 ± 22.2% (mean ± standard deviation) and did not depend on the cause of infertility.
Chronic alcohol use increased the SDFI to 49.6 ± 23.3% compared with 33.9 ± 18.0% in nondrinkers.
The SDFI was related to adverse conventional semen parameters and sperm motion characteristics and correlated with the serum FSH level.
The SNV showed a tendency to increase with the SDFI.
The multivariate analysis revealed that the sperm progressive motility and chronic alcohol use were significant predictors of the SDF.
Conclusion.
The SCDt should be offered to chronic alcohol users and those with decreased sperm progressive motility.
American Psychological Association (APA)
Komiya, A.& Kato, Tomonori& Kawauchi, Yoko& Watanabe, Akihiko& Fuse, Hideki. 2014. Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1051412
Modern Language Association (MLA)
Komiya, A.…[et al.]. Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1051412
American Medical Association (AMA)
Komiya, A.& Kato, Tomonori& Kawauchi, Yoko& Watanabe, Akihiko& Fuse, Hideki. Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1051412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051412