Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis
Joint Authors
Momo, Claudia
Jacintho, Ana Paula Prudente
Moreira, Pamela Rodrigues Reina
Munari, Danísio Prado
Machado, Gisele Fabrino
Vasconcelos, Rosemeri de Oliveira
Source
Veterinary Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to evaluate the most frequent lesions in the bone marrow of dogs naturally infected by Leishmania (Leishmania) chagasi.
Thirty-three dogs sacrificed at the Zoonosis Control Center of Araçatuba, a municipality endemic for visceral leishmaniasis (VL), were used.
The animals were classified as asymptomatic, oligosymptomatic, and symptomatic groups.
At the necropsy, bone marrow samples were collected from the femur, fixed, processed, and stained with hematoxylin and eosin.
The lesion intensity was classified as mild, moderate, or severe.
The parasite load was determined using immunohistochemistry.
The most important lesions consisted of multifocal to diffuse granulomas, megakaryocytic dysplasia, and medullary aplasia.
There were no statistical differences between the three clinical groups regarding parasite load and lesion intensity.
Asymptomatic dogs also presented high parasitism in the bone marrow as dogs with clinical signs of VL.
It was concluded that, regardless of clinical group, the bone marrow is a site for multiplication of Leishmania chagasi.
Possibly, the bone marrow dysplasia may arise from the presence of many parasitized and activated macrophages in this organ.
Consequently, it affects the profile of hematopoietic cells in the bone marrow and systemic circulation.
American Psychological Association (APA)
Momo, Claudia& Jacintho, Ana Paula Prudente& Moreira, Pamela Rodrigues Reina& Munari, Danísio Prado& Machado, Gisele Fabrino& Vasconcelos, Rosemeri de Oliveira. 2014. Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051890
Modern Language Association (MLA)
Momo, Claudia…[et al.]. Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis. Veterinary Medicine International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1051890
American Medical Association (AMA)
Momo, Claudia& Jacintho, Ana Paula Prudente& Moreira, Pamela Rodrigues Reina& Munari, Danísio Prado& Machado, Gisele Fabrino& Vasconcelos, Rosemeri de Oliveira. Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1051890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051890