Effects of Acute Bleeding Followed by Hydroxyethyl Starch 1300.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs
Joint Authors
Silva, Aura
Ortiz, Ana Liza
Venâncio, Carlos
Souza, Almir P.
Ferreira, Luísa Maria
Branco, Paula Sério
de Pinho, Paula Guedes
Amorim, Pedro
Ferreira, David A.
Source
Veterinary Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bleeding changes the haemodynamics, compromising organ perfusion.
In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer’s (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated.
Twelve young pigs under propofol-remifentanil anaesthesia were bled 30 mL/kg and, after a 20-minute waiting period, volume replacement was performed with HES (GHES; N = 6 ) or LR (GRL; N = 6 ).
Bleeding caused a decrease of more than 50% in mean arterial pressure ( P < 0.01 ) and a decrease in cerebral oximetry ( P = 0.039 ), bispectral index, and electroencephalogram total power ( P = 0.04 and P < 0.01 , resp.), while propofol plasma concentrations increased ( P < 0.01 ).
Both solutions restored the haemodynamics and cerebral oxygenation similarly and were accompanied by an increase in electroencephalogram total power.
No differences between groups were found.
However, one hour after the end of the volume replacement, the cardiac output ( P = 0.03 ) and the cerebral oxygenation ( P = 0.008 ) decreased in the GLR and were significantly lower than in GHES ( P = 0.02 ).
Volume replacement with HES 130/0.4 was capable of maintaining the cardiac output and cerebral oxygenation during a longer period than LR and caused a decrease in the propofol plasma concentrations.
American Psychological Association (APA)
Silva, Aura& Ortiz, Ana Liza& Venâncio, Carlos& Souza, Almir P.& Ferreira, Luísa Maria& Branco, Paula Sério…[et al.]. 2014. Effects of Acute Bleeding Followed by Hydroxyethyl Starch 1300.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs. Veterinary Medicine International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051940
Modern Language Association (MLA)
Silva, Aura…[et al.]. Effects of Acute Bleeding Followed by Hydroxyethyl Starch 1300.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs. Veterinary Medicine International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1051940
American Medical Association (AMA)
Silva, Aura& Ortiz, Ana Liza& Venâncio, Carlos& Souza, Almir P.& Ferreira, Luísa Maria& Branco, Paula Sério…[et al.]. Effects of Acute Bleeding Followed by Hydroxyethyl Starch 1300.4 or a Crystalloid on Propofol Concentrations, Cerebral Oxygenation, and Electroencephalographic and Haemodynamic Variables in Pigs. Veterinary Medicine International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1051940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051940