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Comparison of Histochemical Stainings in Evaluation of Liver Fibrosis and Correlation with Transient Elastography in Chronic Hepatitis
Joint Authors
Maida, Marcello
Cabibi, Daniela
Bronte, Fabrizio
Porcasi, Rossana
Ingrao, Sabrina
Giannone, Antonino Giulio
Grazia Bavetta, Maria
Petta, Salvatore
Di Marco, Vito
Calvaruso, Vincenza
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
The best staining to evaluate liver fibrosis in liver hepatitis is still a debated topic.
This study aimed to compare Masson’s trichrome (MT), Sirius Red (SR), and orcein stainings in evaluating liver fibrosis in chronic HCV hepatitis (CHC) with semiquantitative and quantitative methods (Collagen Proportionate Area (CPA) by Digital Image Analysis (DIA)) and correlate them with transient elastography (TE).
Methods.
Liver stiffness evaluation of 111 consecutive patients with CHC was performed by TE.
Semiquantitative staging by Metavir score system and CPA by DIA were assessed on liver biopsy stained with MT, SR, and orcein.
Results.
MT, SR, and orcein staining showed concordant results in 89.6% of cases in staging CHC, without significant difference in both semiquantitative and quantitative evaluations of fibrosis.
TE values were concordant with orcein levels in 86.5% of the cases and with MT/RS in 77.5% ( P < 0.001 ).
No significant correlation between the grade of necroinflammatory activity and TE values was found.
Conclusion.
In CHC, SR/MT and orcein stainings are almost concordant and when discordant, orcein staining is better related to TE values than MT/RS.
This suggests that elastic fibers play a more important role than reticular or collagenous ones in determining stiffness values in CHC.
American Psychological Association (APA)
Cabibi, Daniela& Bronte, Fabrizio& Porcasi, Rossana& Ingrao, Sabrina& Giannone, Antonino Giulio& Maida, Marcello…[et al.]. 2015. Comparison of Histochemical Stainings in Evaluation of Liver Fibrosis and Correlation with Transient Elastography in Chronic Hepatitis. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052355
Modern Language Association (MLA)
Cabibi, Daniela…[et al.]. Comparison of Histochemical Stainings in Evaluation of Liver Fibrosis and Correlation with Transient Elastography in Chronic Hepatitis. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052355
American Medical Association (AMA)
Cabibi, Daniela& Bronte, Fabrizio& Porcasi, Rossana& Ingrao, Sabrina& Giannone, Antonino Giulio& Maida, Marcello…[et al.]. Comparison of Histochemical Stainings in Evaluation of Liver Fibrosis and Correlation with Transient Elastography in Chronic Hepatitis. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052355