Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India
Joint Authors
Bhattacharya, Prasun
Datta, Suvro Sankha
Mukherjee, Somnath
Talukder, Biplabendu
Mukherjee, Krishnendu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Red blood cell (RBC) alloimmunization and autoimmunization remain a major problem in transfusion dependent thalassemic patients.
There is a paucity of data on the incidence of RBC alloimmunization and autoimmunization in thalassemic patients from eastern part of India, as pretransfusion antibody screening is not routinely performed.
Aims.
To assess the incidence of RBC alloimmunization and autoimmunization in transfusion dependent thalassemic patients in eastern India.
Materials and Methods.
Total 500 thalassemia cases were evaluated.
The antibody screening and identification were performed with commercially available panel cells (Diapanel, Bio-rad, Switzerland) by column agglutination method.
To detect autoantibodies, autocontrol and direct antiglobulin tests were carried out using polyspecific coombs (IgG + C3d) gel cards in all patients.
Results.
A total of 28 patients developed RBC alloimmunization (5.6%) and 5 patients had autoantibodies (1%).
Alloantibody against c had the highest incidence (28.57%) followed by E (21.42%).
Five out of 28 (17.85%) patients had developed antibodies against both c and E.
Conclusion.
Data from this study demonstrate that the RBC alloantibody and autoantibody development rates are significant in our region.
Thus, pretransfusion antibody screening needs to be initiated in eastern India in order to ensure safe transfusion practice.
American Psychological Association (APA)
Datta, Suvro Sankha& Mukherjee, Somnath& Talukder, Biplabendu& Bhattacharya, Prasun& Mukherjee, Krishnendu. 2015. Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India. Advances in Hematology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1052444
Modern Language Association (MLA)
Datta, Suvro Sankha…[et al.]. Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India. Advances in Hematology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1052444
American Medical Association (AMA)
Datta, Suvro Sankha& Mukherjee, Somnath& Talukder, Biplabendu& Bhattacharya, Prasun& Mukherjee, Krishnendu. Frequency of Red Cell Alloimmunization and Autoimmunization in Thalassemia Patients: A Report from Eastern India. Advances in Hematology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1052444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052444