Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice

Joint Authors

Schaefer, Roland
Virgin, Garth
Geisel, Tabea
Stein, Jürgen
Bach, Matthias
Martin, Julia
Schulze, Bettina

Source

Anemia

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-07-05

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Current iron supplementation practice in geriatric patients is erratic and lacks evidence-based recommendations.

Despite potential benefits in this population, intravenous iron supplementation is often withheld due to concerns regarding pharmacy expense, perceived safety issues, and doubts regarding efficacy in elderly patients.

This retrospective, observational cohort study aimed to evaluate the safety and efficacy of intravenous ferric carboxymaltose (FCM, Ferinject) in patients aged >75 years with iron deficiency anaemia (IDA).

Within a twelve-month data extraction period, the charts of 405 hospitalised patients aged 65–101 years were retrospectively analysed for IDA, defined according to WHO criteria for anaemia (haemoglobin: <13.0 g/dL (m)/<12.0 g/dL (f)) in conjunction with transferrin saturation <20%.

Of 128 IDA patients screened, 51 (39.8%) received intravenous iron.

38 patient charts were analysed.

Mean cumulative dose of intravenous FCM was 784.4 ± 271.7 mg iron (1–3 infusions).

18 patients (47%) fulfilled treatment response criteria (≥1.0 g/dL increase in haemoglobin between baseline and hospital discharge).

AEs were mild/moderate, most commonly transient increases of liver enzymes (n = 5/13.2%).

AE incidence was comparable with that observed in patients <75 years.

No serious AEs were observed.

Ferric carboxymaltose was well tolerated and effective for correction of Hb levels and iron stores in this cohort of IDA patients aged over 75 years.

American Psychological Association (APA)

Bach, Matthias& Geisel, Tabea& Martin, Julia& Schulze, Bettina& Schaefer, Roland& Virgin, Garth…[et al.]. 2015. Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice. Anemia،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053782

Modern Language Association (MLA)

Bach, Matthias…[et al.]. Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice. Anemia No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1053782

American Medical Association (AMA)

Bach, Matthias& Geisel, Tabea& Martin, Julia& Schulze, Bettina& Schaefer, Roland& Virgin, Garth…[et al.]. Efficacy and Safety of Intravenous Ferric Carboxymaltose in Geriatric Inpatients at a German Tertiary University Teaching Hospital: A Retrospective Observational Cohort Study of Clinical Practice. Anemia. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053782

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1053782