Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey
Joint Authors
Picot, Carene M. N.
Mahmudi, M. Fawzi
Zengin, Gokhan
Guler, Gokalp Ozmen
Aktumsek, Abdurrahman
Ceylan, Ramazan
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase).
The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays.
The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH•), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts.
The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and α-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively.
The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were significantly higher than trolox.
The phenol and flavonoid contents of the plant extracts were in the range 20.90 ± 0.190 – 83.25 ± 0.914 mg gallic acid equivalent/g extract and 1.45 ± 0.200 – 39.71 ± 0.092 mg rutin equivalent/g extract, respectively.
The plants were found to possess moderate antioxidant capacities and interesting inhibitory action against key enzymes.
American Psychological Association (APA)
Zengin, Gokhan& Guler, Gokalp Ozmen& Aktumsek, Abdurrahman& Ceylan, Ramazan& Picot, Carene M. N.& Mahmudi, M. Fawzi. 2015. Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053904
Modern Language Association (MLA)
Zengin, Gokhan…[et al.]. Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey. Advances in Pharmacological and Pharmaceutical Sciences No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1053904
American Medical Association (AMA)
Zengin, Gokhan& Guler, Gokalp Ozmen& Aktumsek, Abdurrahman& Ceylan, Ramazan& Picot, Carene M. N.& Mahmudi, M. Fawzi. Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey. Advances in Pharmacological and Pharmaceutical Sciences. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1053904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053904