Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide
Joint Authors
Idemudia, Omoruyi Gold
Sadimenko, Alexander P.
Hosten, Eric C.
Afolayan, Anthony Jide
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Two Schiff base ligands Ampp-Sn 1 and Bmpp-Sn 2, afforded by a condensation reaction between sulfanilamide and the respective acylpyrazolone carbonyl precursors, their Mn(II), Co(II), Ni(II), and Cu(II) complexes prepared by the reaction of ligands and corresponding metal salts in aqueous solutions, were synthesized and then characterized by both analytical and spectroscopic methods, in a view to developing new improved bioactive materials with novel properties.
On the basis of elemental analysis, spectroscopic and TGA results, transition metal complexes, with octahedral geometry having two molecules of the bidentate keto-imine ligand each, have been proposed.
The single crystal structure of Bmpp-Sn according to X-ray crystallography showed a keto-imine tautomer type of Schiff base, having three intramolecular bonds, one short N2 ⋯ H2 ⋯ O3 hydrogen bond of 1.90 Å and two long C13 ⋯ H13 ⋯ O2 and C32 ⋯ H32 ⋯ O3 hydrogen bonds of 2.48 Å.
A moderate to low biological activities have been exhibited by synthesized compounds when compared with standard antimicrobial agents on screening the synthesized compounds against Staphylococcus aureus, Bacillus pumilus, Proteus vulgaris, and Aeromonas hydrophila for antibacterial activity and against free radical 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) for antioxidant activity.
American Psychological Association (APA)
Idemudia, Omoruyi Gold& Sadimenko, Alexander P.& Afolayan, Anthony Jide& Hosten, Eric C.. 2015. Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054052
Modern Language Association (MLA)
Idemudia, Omoruyi Gold…[et al.]. Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054052
American Medical Association (AMA)
Idemudia, Omoruyi Gold& Sadimenko, Alexander P.& Afolayan, Anthony Jide& Hosten, Eric C.. Synthesis and Characterization of Bioactive Acylpyrazolone Sulfanilamides and Their Transition Metal Complexes: Single Crystal Structure of 4-Benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one Sulfanilamide. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054052