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Salvage Pelvic Lymph Node Dissection in Recurrent Prostate Cancer: Surgical and Early Oncological Outcome
Joint Authors
Claeys, Tom
Van Praet, Charles
Fonteyne, Valérie
Lambert, Bieke
Delrue, Louke
De Visschere, Pieter
Villeirs, Geert
Decaestecker, Karel
Ost, Piet
De Meerleer, Gert
Lumen, Nicolaas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Methodology.
Seventeen patients with prostate-specific antigen (PSA) rise following local treatment for prostate cancer with curative intent underwent open or minimally invasive salvage pelvic lymph node dissection (SLND) for oligometastatic disease (<4 synchronous metastases) or as staging prior to salvage radiotherapy.
Biochemical recurrence after complete biochemical response (cBR) was defined as 2 consecutive PSA increases >0,2 ng/mL; and after incomplete biochemical response as 2 consecutive PSA rises.
Newly found metastasis on imaging defined clinical progression (CP).
Palliative androgen deprivation therapy (ADT) was initiated if >3 metastases were detected or if patients became symptomatic.
Kaplan-Meier statistics were applied.
Results.
Clavien-Dindo grade 1, 2, 3a, and 3b complications were seen in 6, 1, 1, and 2 patients, respectively.
Median follow-up time was 22 months.
Among 13 patients treated for oligometastatic disease, 8 (67%) had a PSA decline, with 3 patients showing cBR.
Median PSA progression-free survival (FS) was 4.1 months and median CP-FS 7 months.
Three patients started ADT, resulting in a 2-year ADT-FS rate of 79.5%.
Conclusion.
SLND is feasible, but postoperative complication rate seems higher than that for primary LND.
Biochemical and clinical response duration is limited, but as part of an oligometastatic treatment regime it can defer palliative ADT.
American Psychological Association (APA)
Claeys, Tom& Van Praet, Charles& Lumen, Nicolaas& Ost, Piet& Fonteyne, Valérie& De Meerleer, Gert…[et al.]. 2015. Salvage Pelvic Lymph Node Dissection in Recurrent Prostate Cancer: Surgical and Early Oncological Outcome. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054606
Modern Language Association (MLA)
Claeys, Tom…[et al.]. Salvage Pelvic Lymph Node Dissection in Recurrent Prostate Cancer: Surgical and Early Oncological Outcome. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054606
American Medical Association (AMA)
Claeys, Tom& Van Praet, Charles& Lumen, Nicolaas& Ost, Piet& Fonteyne, Valérie& De Meerleer, Gert…[et al.]. Salvage Pelvic Lymph Node Dissection in Recurrent Prostate Cancer: Surgical and Early Oncological Outcome. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054606