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Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature
Joint Authors
Di Nicola, Maura
Barteselli, Giulio
Dell’Arti, Laura
Ratiglia, Roberto
Viola, Francesco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Deferoxamine mesylate (DFO) is the most commonly used iron-chelating agent to treat transfusion-related hemosiderosis.
Despite the clear advantages for the use of DFO, numerous DFO-related systemic toxicities have been reported in the literature, as well as sight-threatening ocular toxicity involving the retinal pigment epithelium (RPE).
The damage to the RPE can lead to visual field defects, color-vision defects, abnormal electrophysiological tests, and permanent visual deterioration.
The purpose of this review is to provide an updated summary of the ocular findings, including both functional and structural abnormalities, in DFO-treated patients.
In particular, we pay particular attention to analyzing results of multimodal technologies for retinal imaging, which help ophthalmologists in the early diagnosis and correct management of DFO retinopathy.
Fundus autofluorescence, for example, is not only useful for screening patients at high-risk of DFO retinopathy, but is also a prerequisite for identify specific high-risk patterns of RPE changes that are relevant for the prognosis of the disease.
In addition, optical coherence tomography may have a clinical usefulness in detecting extent and location of different retinal changes in DFO retinopathy.
Finally, this review wants to underline the need for universally approved guidelines for screening and followup of this particular disease.
American Psychological Association (APA)
Di Nicola, Maura& Barteselli, Giulio& Dell’Arti, Laura& Ratiglia, Roberto& Viola, Francesco. 2015. Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054751
Modern Language Association (MLA)
Di Nicola, Maura…[et al.]. Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054751
American Medical Association (AMA)
Di Nicola, Maura& Barteselli, Giulio& Dell’Arti, Laura& Ratiglia, Roberto& Viola, Francesco. Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054751