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Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery
Joint Authors
Kuhn, Elmar W.
Choi, Yeong-Hoon
Pyun, Jung-Min
Neef, Klaus
Liakopoulos, Oliver J.
Stamm, Christof
Wittwer, Thorsten
Wahlers, Thorsten
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this investigation was to analyze the impact of intermittent cold blood cardioplegia (ICC) and intermittent warm blood cardioplegia (IWC) on endothelial injury in patients referred to elective on-pump coronary artery bypass graft (CABG) surgery.
Patients undergoing CABG procedures were randomized to either ICC or IWC.
Myocardial injury was assessed by CK-MB and cardiac troponin T (cTnT).
Endothelial injury was quantified by circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble thrombomodulin (sTM).
Perioperative myocardial injury (PMI) and major adverse cardiac events (MACE) were recorded.
Demographic data and preoperative risk profile of included patients (ICC: n=32, IWC: n=36) were comparable.
No deaths, PMI, or MACE were observed.
Levels of CK-MB and cTnT did not show intergroup differences.
Concentrations of CECs peaked at 6 h postoperatively with significantly higher values for IWC-patients at 1 h (ICC: 10.1 ± 3.9/mL; IWC: 18.4 ± 4.1/mL; P=0.012) and 6 h (ICC: 19.3 ± 6.2/mL; IWC: 29.2 ± 6.7/mL; P<0.001).
Concentrations of vWF (ICC: 178.4 ± 73.2 U/dL; IWC: 258.2 ± 89.7 U/dL; P<0.001) and sTM (ICC: 3.2 ± 2.1 ng/mL; IWC: 5.2 ± 2.4 ng/mL; P=0.011) were significantly elevated in IWC-group at 1 h postoperatively.
This study shows that the use of IWC is associated with a higher extent of endothelial injury compared to ICC without differences in clinical endpoints.
American Psychological Association (APA)
Kuhn, Elmar W.& Choi, Yeong-Hoon& Pyun, Jung-Min& Neef, Klaus& Liakopoulos, Oliver J.& Stamm, Christof…[et al.]. 2015. Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054774
Modern Language Association (MLA)
Kuhn, Elmar W.…[et al.]. Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054774
American Medical Association (AMA)
Kuhn, Elmar W.& Choi, Yeong-Hoon& Pyun, Jung-Min& Neef, Klaus& Liakopoulos, Oliver J.& Stamm, Christof…[et al.]. Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054774