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Neuronal Nitric Oxide Synthase Is Dislocated in Type I Fibers of Myalgic Muscle but Can Recover with Physical Exercise Training
Joint Authors
Sjøgaard, Gisela
Jensen, L.
Andersen, L. L.
Schrøder, H. D.
Frandsen, U.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Trapezius myalgia is the most common type of chronic neck pain.
While physical exercise reduces pain and improves muscle function, the underlying mechanisms remain unclear.
Nitric oxide (NO) signaling is important in modulating cellular function, and a dysfunctional neuronal NO synthase (nNOS) may contribute to an ineffective muscle function.
This study investigated nNOS expression and localization in chronically painful muscle.
Forty-one women clinically diagnosed with trapezius myalgia (MYA) and 18 healthy controls (CON) were included in the case-control study.
Subsequently, MYA were randomly assigned to either 10 weeks of specific strength training (SST, n = 18 ), general fitness training (GFT, n = 15 ), or health information (REF, n = 8 ).
Distribution of fiber type, cross-sectional area, and sarcolemmal nNOS expression did not differ between MYA and CON.
However, MYA showed increased sarcoplasmic nNOS localization (18.8 ± 12 versus 12.8 ± 8%, P = 0.049 ) compared with CON.
SST resulted in a decrease of sarcoplasm-localized nNOS following training (before 18.1 ± 12 versus after 12.0 ± 12%; P = 0 ,027).
We demonstrate that myalgic muscle displays altered nNOS localization and that 10 weeks of strength training normalize these disruptions, which supports previous findings of impaired muscle oxygenation during work tasks and reduced pain following exercise.
American Psychological Association (APA)
Jensen, L.& Andersen, L. L.& Schrøder, H. D.& Frandsen, U.& Sjøgaard, Gisela. 2015. Neuronal Nitric Oxide Synthase Is Dislocated in Type I Fibers of Myalgic Muscle but Can Recover with Physical Exercise Training. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054816
Modern Language Association (MLA)
Jensen, L.…[et al.]. Neuronal Nitric Oxide Synthase Is Dislocated in Type I Fibers of Myalgic Muscle but Can Recover with Physical Exercise Training. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054816
American Medical Association (AMA)
Jensen, L.& Andersen, L. L.& Schrøder, H. D.& Frandsen, U.& Sjøgaard, Gisela. Neuronal Nitric Oxide Synthase Is Dislocated in Type I Fibers of Myalgic Muscle but Can Recover with Physical Exercise Training. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054816