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Clinical Significance of Neutrophil Gelatinase-Associated Lipocalin in Crimean-Congo Hemorrhagic Fever
Joint Authors
Cure, Erkan
Yuce, Suleyman
Erturk, Ayse
Parlak, Emine
Sahin, Serap Baydur
Cumhur Cure, Medine
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Neutrophil gelatinase-associated lipocalin (NGAL), which is an important prognostic marker for sepsis and inflammatory diseases, is mostly released from neutrophils.
Crimean-Congo hemorrhagic fever (CCHF) patients are generally neutropenic.
We aimed to investigate whether there is a change in serum NGAL level and to investigate its effect on the recovery time (RT) during the course of CCHF.
A total of 40 CCHF patients (19 females and 21 males) and 34 healthy controls (17 females and 17 males) were included in the study.
The serum NGAL level and biochemical and hematological parameters were checked.
The NGAL level of CCHF patients was significantly higher than that of the healthy controls ( P < 0.001 ).
A multivariate analysis showed that the independent prognostic factor for the prediction of the RT is the NGAL level (odds ratio [OR] 0.3, 95% confidence interval [Cl] 0.1–0.4, P < 0.001 ).
An elevated NGAL level was found to be associated with an increased RT in CCHF patients.
The NGAL levels of CHHF patients might be elevated due to increased cytokine release, the presence of a tissue injury, and the release of immature neutrophils from the bone marrow into the peripheral stream.
This may be a good prognostic factor in CHHF patients.
American Psychological Association (APA)
Erturk, Ayse& Cure, Erkan& Parlak, Emine& Cumhur Cure, Medine& Sahin, Serap Baydur& Yuce, Suleyman. 2015. Clinical Significance of Neutrophil Gelatinase-Associated Lipocalin in Crimean-Congo Hemorrhagic Fever. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055234
Modern Language Association (MLA)
Erturk, Ayse…[et al.]. Clinical Significance of Neutrophil Gelatinase-Associated Lipocalin in Crimean-Congo Hemorrhagic Fever. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1055234
American Medical Association (AMA)
Erturk, Ayse& Cure, Erkan& Parlak, Emine& Cumhur Cure, Medine& Sahin, Serap Baydur& Yuce, Suleyman. Clinical Significance of Neutrophil Gelatinase-Associated Lipocalin in Crimean-Congo Hemorrhagic Fever. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1055234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055234