The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats
Joint Authors
El Rabey, Haddad A.
al-Malki, Abdulrahman L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The antidiabetic activity of two low doses of Moringa seed powder (50 and 100 mg/kg body weight, in the diet) on streptozotocin (STZ) induced diabetes male rats was investigated.
Forty rats were divided into four groups.
The diabetic positive control (STZ treated) group showed increased lipid peroxide, increased IL-6, and decreased antioxidant enzyme in the serum and kidney tissue homogenate compared with that of the negative control group.
Immunoglobulins (IgA, IgG), fasting blood sugar, and glycosylated hemoglobin ( H b A 1 c ) were also increased as a result of diabetes in G2 rats.
Moreover albumin was decreased, and liver enzymes and α-amylase were not affected.
In addition, the renal functions and potassium and sodium levels in G2 were increased as a sign of diabetic nephropathy.
Urine analysis showed also glucosuria and increased potassium, sodium, creatinine, uric acid, and albumin levels.
Kidney and pancreas tissues showed also pathological alteration compared to the negative control group.
Treating the diabetic rats with 50 or 100 mg Moringa seeds powder/kg body weight in G3 and G4, respectively, ameliorated the levels of all these parameters approaching the negative control values and restored the normal histology of both kidney and pancreas compared with that of the diabetic positive control group.
American Psychological Association (APA)
al-Malki, Abdulrahman L.& El Rabey, Haddad A.. 2015. The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055255
Modern Language Association (MLA)
al-Malki, Abdulrahman L.& El Rabey, Haddad A.. The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1055255
American Medical Association (AMA)
al-Malki, Abdulrahman L.& El Rabey, Haddad A.. The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1055255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055255