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Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding
Joint Authors
Shahrour, Khaled
Keck, Rick
Jankun, Jerzy
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
PAI-1 prevents lysis of blood clot by inhibiting the urokinase and tPA induced conversion of plasminogen to plasmin.
VLHL PAI-1 protein mutant was created to extend half-life over 700 hours.
The objective of this paper was to test VLHL PAI-1 effects on bleeding during partial nephrectomy in mice.
All animals had a left partial nephrectomy after intravenous infusion of saline or tPA.
The animals were divided into four groups.
Group 1 was infused with saline and kidney was exposed to saline too; Group 2 was infused with saline and kidney was exposed to PAI-1.
Group 3 was infused with tPA and kidney was exposed to saline, while Group 4 was infused with tPA and kidney was exposed to PAI-1.
Preweighed gauze containing PAI-1 or saline was then applied to the kidney for 30 minutes.
The gauze was afterward weighed and blood loss was measured by subtracting the preweight of gauze from the final weight.
We have observed a statistically significant (P≤0.05) reduction of bleeding in PAI-1-treated group in comparison to saline and tPA-treated groups.
Based on these results we propose that VLHL PAI-1 can be used therapeutically in limiting the flow of blood from renal wounds.
American Psychological Association (APA)
Shahrour, Khaled& Keck, Rick& Jankun, Jerzy. 2015. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
Modern Language Association (MLA)
Shahrour, Khaled…[et al.]. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
American Medical Association (AMA)
Shahrour, Khaled& Keck, Rick& Jankun, Jerzy. Application of Long-Acting VLHL PAI-1 during Sutureless Partial Nephrectomy in Mice Reduces Bleeding. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1055300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055300