Fully Automated Quantification of the Striatal Uptake Ratio of [99mTc]-TRODAT with SPECT Imaging: Evaluation of the Diagnostic Performance in Parkinson’s Disease and the Temporal Regression of Striatal Tracer Uptake
Joint Authors
Chiu, Shao-Chieh
Lu, Chin-Song
Weng, Yi-Hsin
Yen, Tzu-Chen
Fang, Yu-Hua Dean
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
We aimed at improving the existing methods for the fully automatic quantification of striatal uptake of [Tc99m]-TRODAT with SPECT imaging.
Procedures.
A normal [Tc99m]-TRODAT template was first formed based on 28 healthy controls.
Images from PD patients (n=365) and nPD subjects (28 healthy controls and 33 essential tremor patients) were spatially normalized to the normal template.
We performed an inverse transform on the predefined striatal and reference volumes of interest (VOIs) and applied the transformed VOIs to the original image data to calculate the striatal-to-reference ratio (SRR).
The diagnostic performance of the SRR was determined through receiver operating characteristic (ROC) analysis.
Results.
The SRR measured with our new and automatic method demonstrated excellent diagnostic performance with 92% sensitivity, 90% specificity, 92% accuracy, and an area under the curve (AUC) of 0.94.
For the evaluation of the mean SRR and the clinical duration, a quadratic function fit the data with R2=0.84.
Conclusions.
We developed and validated a fully automatic method for the quantification of the SRR in a large study sample.
This method has an excellent diagnostic performance and exhibits a strong correlation between the mean SRR and the clinical duration in PD patients.
American Psychological Association (APA)
Fang, Yu-Hua Dean& Chiu, Shao-Chieh& Lu, Chin-Song& Yen, Tzu-Chen& Weng, Yi-Hsin. 2015. Fully Automated Quantification of the Striatal Uptake Ratio of [99mTc]-TRODAT with SPECT Imaging: Evaluation of the Diagnostic Performance in Parkinson’s Disease and the Temporal Regression of Striatal Tracer Uptake. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055569
Modern Language Association (MLA)
Fang, Yu-Hua Dean…[et al.]. Fully Automated Quantification of the Striatal Uptake Ratio of [99mTc]-TRODAT with SPECT Imaging: Evaluation of the Diagnostic Performance in Parkinson’s Disease and the Temporal Regression of Striatal Tracer Uptake. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1055569
American Medical Association (AMA)
Fang, Yu-Hua Dean& Chiu, Shao-Chieh& Lu, Chin-Song& Yen, Tzu-Chen& Weng, Yi-Hsin. Fully Automated Quantification of the Striatal Uptake Ratio of [99mTc]-TRODAT with SPECT Imaging: Evaluation of the Diagnostic Performance in Parkinson’s Disease and the Temporal Regression of Striatal Tracer Uptake. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1055569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055569