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Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy
Joint Authors
Williams, Lynne K.
Chan, Raymond H.
Carasso, Shemy
Durand, Miranda
Misurka, Jimmy
Ralph-Edwards, Anthony
Gruner, Christiane
Woo, Anna
Lesser, John R.
Maron, Barry J.
Maron, Martin S.
Rakowski, Harry
Crean, Andrew M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Left atrial (LA) volumes are known to be increased in hypertrophic cardiomyopathy (HCM) and are a predictor of adverse outcome.
In addition, LA function is impaired and is presumed to be due to left ventricular (LV) diastolic dysfunction as a result of hypertrophy and myocardial fibrosis.
In the current study, we assess the incremental effect of outflow tract obstruction (and concomitant mitral regurgitation) on LA function as assessed by LA strain.
Patients with HCM (50 obstructive, 50 nonobstructive) were compared to 50 normal controls.
A subset of obstructive patients who had undergone septal myectomy was also studied.
Utilising feature-tracking software applied to cardiovascular magnetic resonance images, LA volumes and functional parameters were calculated.
LA volumes were significantly elevated and LA ejection fraction and strain were significantly reduced in patients with HCM compared with controls and were significantly more affected in patients with obstruction.
LA volumes and function were significantly improved after septal myectomy.
LVOT obstruction and mitral regurgitation appear to further impair LA mechanics.
Septal myectomy results in a significant reduction in LA volumes, paralleled by an improvement in function.
American Psychological Association (APA)
Williams, Lynne K.& Chan, Raymond H.& Carasso, Shemy& Durand, Miranda& Misurka, Jimmy& Crean, Andrew M.…[et al.]. 2015. Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055637
Modern Language Association (MLA)
Williams, Lynne K.…[et al.]. Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1055637
American Medical Association (AMA)
Williams, Lynne K.& Chan, Raymond H.& Carasso, Shemy& Durand, Miranda& Misurka, Jimmy& Crean, Andrew M.…[et al.]. Effect of Left Ventricular Outflow Tract Obstruction on Left Atrial Mechanics in Hypertrophic Cardiomyopathy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1055637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055637