Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns
Joint Authors
Chen, Shun
Qi, Yulin
Wang, Mingshu
Zhu, Dekang
Liu, Mafeng
Chen, Xiaoyue
Cheng, Anchun
Zhou, Hao
Zhou, Qin
Jia, Renyong
Liu, Fei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Interferon γ receptor 1 (IFNGR1) and IFNGR2 are two cell membrane molecules belonging to class II cytokines, which play important roles in the IFN-mediated antiviral signaling pathway.
Here, goose IFNGR1 and IFNGR2 were cloned and identified for the first time.
Tissue distribution analysis revealed that relatively high levels of goose IFNγ mRNA transcripts were detected in immune tissues, including the harderian gland, cecal tonsil, cecum, and thymus.
Relatively high expression levels of both IFNGR1 and IFNGR2 were detected in the cecal tonsil, which implicated an important role of IFNγ in the secondary immune system of geese.
No specific correlation between IFNγ, IFNGR1, and IFNGR2 expression levels was observed in the same tissues of healthy geese.
IFNγ and its cognate receptors showed different expression profiles, although they appeared to maintain a relatively balanced state.
Furthermore, the agonist R848 led to the upregulation of goose IFNγ but did not affect the expression of goose IFNGR1 or IFNGR2.
In summary, trends in expression of goose IFNγ and its cognate receptors showed tissue specificity, as well as an age-related dependency.
These findings may help us to better understand the age-related susceptibility to pathogens in birds.
American Psychological Association (APA)
Zhou, Hao& Chen, Shun& Qi, Yulin& Zhou, Qin& Wang, Mingshu& Jia, Renyong…[et al.]. 2015. Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055868
Modern Language Association (MLA)
Zhou, Hao…[et al.]. Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1055868
American Medical Association (AMA)
Zhou, Hao& Chen, Shun& Qi, Yulin& Zhou, Qin& Wang, Mingshu& Jia, Renyong…[et al.]. Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1055868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055868