Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time
Joint Authors
Lee, Byung-Wan
Cha, Bong Soo
Lee, Hyun Chul
Kim, Kwang Joon
Yoon, Hye-jin
Kim, So Ra
Kang, Eun Seok
Lee, Yong-ho
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function.
Based on this, we investigated whether GA increases with time relative to glycated hemoglobin (HbA1c) and the association between GA and beta-cell function.
We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years.
We assessed the pattern of changes with time in glycemic indices (GA, HbA1c, and GA/HbA1c ratio) and their relationship with beta-cell function.
In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months.
However, from 39 months to 51 months, GA significantly increased but HbA1c tended to increase without statistical significance.
We defined ΔGA/HbA1c as the difference between the nadir point (at 15 to 27 months) and the end point (at 39 to 51 months) and found that ΔGA/HbA1c was positively correlated with diabetes duration and negatively related to beta-cell function.
In multivariable linear regression analyses, ΔGA/HbA1c was independently associated with diabetes duration.
In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time.
American Psychological Association (APA)
Yoon, Hye-jin& Lee, Yong-ho& Kim, Kwang Joon& Kim, So Ra& Kang, Eun Seok& Cha, Bong Soo…[et al.]. 2015. Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055979
Modern Language Association (MLA)
Yoon, Hye-jin…[et al.]. Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055979
American Medical Association (AMA)
Yoon, Hye-jin& Lee, Yong-ho& Kim, Kwang Joon& Kim, So Ra& Kang, Eun Seok& Cha, Bong Soo…[et al.]. Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055979