Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
Joint Authors
Wu, Jing
Wu, Jianfeng
Gu, Jiajia
Chen, Meng
Wang, De-Jun
Zong, Dan
Guo, Chang
Zhu, Huan-Feng
He, Xia
Yin, Li
Jiang, Xuesong
Guo, Wenjie
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with the tumor volume and prognosis in patients with locally advanced nasopharyngeal carcinoma (NPC).
A total of 165 patients with newly diagnosed locally advanced NPC were identified from September 2011 to July 2012.
EBV-DNA was detected using fluorescence quantitative polymerase chain reaction (PCR) amplification.
The tumor volume was calculated by the systematic summation method of computer software.
The median copy number of plasma EBV-DNA before treatment was 3790 copies/mL.
The median gross tumor volume of the primary nasopharyngeal tumor (GTVnx), the lymph node lesions (GTVnd), and the total GTV before treatment were 72.46, 23.26, and 106.25 cm3, respectively; the EBV-DNA levels were significantly correlated with the GTVnd and the total GTV ( P < 0.01 ).
The 2-year overall survival (OS) rates in patients with positive and negative pretreatment plasma EBV-DNA were 100% and 98.4% ( P = 1.000 ), and the disease-free survival (DFS) rates were 94.4% and 80.8% ( P = 0.044 ), respectively.
These results indicate that high pretreatment plasma EBV-DNA levels in patients with locally advanced NPC are associated with the degree of lymph node metastasis, tumor burden, and poor prognosis.
American Psychological Association (APA)
Chen, Meng& Yin, Li& Wu, Jing& Gu, Jiajia& Jiang, Xuesong& Wang, De-Jun…[et al.]. 2015. Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056144
Modern Language Association (MLA)
Chen, Meng…[et al.]. Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056144
American Medical Association (AMA)
Chen, Meng& Yin, Li& Wu, Jing& Gu, Jiajia& Jiang, Xuesong& Wang, De-Jun…[et al.]. Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056144