Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging
Joint Authors
Zhang, Guo-Yi
Wang, Yue-Jian
Chen, Xiang-Ping
Xu, Tao
Wei, Wei-Hong
Hu, Xue-Feng
Huang, Guo-Sen
Zhou, Miao-Miao
Huang, Ze-Li
Huang, Ying
Liu, Lizhi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To subclassify parapharyngeal extension in nasopharyngeal carcinoma (NPC) and investigate its prognostic value and staging categories based on magnetic resonance imaging (MRI).
Methods and Materials.
Data from 1504 consecutive NPC patients treated with definitive-intent radiotherapy were analyzed retrospectively.
Sites of parapharyngeal extension were defined by MRI.
Overall survival (OS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by the Kaplan-Meier method and compared with the log-rank test.
Hazard consistency and hazard discrimination were determined by multivariate analysis with Cox proportional hazards models.
Results.
1104 patients (73.4%) had parapharyngeal extension; 1.7–63.8% had involvement of various anatomic sites.
The hazard ratio for death was significantly higher with extensive parapharyngeal extension (lateral pterygoid muscle of masticator space and beyond or parotid space) than with mild extension (medial pterygoid muscle of masticator space, or carotid, prestyloid, and prevertebral or retropharyngeal space).
OS, LRFS, and DMFS with extensive parapharyngeal extension were similar to those in T4 disease; OS, LRFS, and DMFS with mild parapharyngeal extension were significantly higher than in those T3 disease (all P ≤ 0.015).
Conclusions.
Parapharyngeal extension in NPC should be subclassified as mild or extensive, which should be regarded as stages T2 and T4 diseases, respectively.
American Psychological Association (APA)
Zhang, Guo-Yi& Huang, Ying& Hu, Xue-Feng& Chen, Xiang-Ping& Xu, Tao& Liu, Lizhi…[et al.]. 2015. Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056612
Modern Language Association (MLA)
Zhang, Guo-Yi…[et al.]. Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056612
American Medical Association (AMA)
Zhang, Guo-Yi& Huang, Ying& Hu, Xue-Feng& Chen, Xiang-Ping& Xu, Tao& Liu, Lizhi…[et al.]. Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056612