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Surgical Modification of the Murine Calvaria Osteolysis Model
Joint Authors
Al-quhali, Ali Mohammed
Sun, Yu
Bai, Xizhuang
Jin, Zhe
Yu, Guibo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The murine calvaria model has been adopted for evaluation of osteolysis and inflammation induced by polyethylene (PE) or metal wear debris.
However, this model suffers from several complications.
The purpose of our study is to introduce a surgical modification with lower complication rates, thus providing more accurate results.
Forty C57/BL6 mice were divided into two groups, both receiving polyethylene particles.
Surgical modifications were performed in group 1, and group 2 underwent traditional surgeries.
The incidence of fluid leakage was recorded on the operative day.
Curst formation, wound dehiscence, and bone exposure were recorded on day 7.
Histological osteolysis was demonstrated by HE staining of tissue slices.
Micro-CT was used for quantifying evaluation of osteolysis in two groups.
Intraoperative fluid leakage was significantly reduced in group 1.
Postoperative crust formation, wound dehiscence, and bone exposure were also significantly decreased in group 1.
HE staining results revealed obvious osteolysis in group 1 and more obvious osteolysis in group 2.
Bone volume fraction (BVF) was (0.32 ± 0.03) in group 1 compared to group 2 (0.24 ± 0.05).
Bone mineral density (BMD) was (1.11 ± 0.03) in group 1 compared to group 2 (1.01 ± 0.02).
Surgical modifications provide a reliable way for establishment of the murine calvaria osteolysis model.
American Psychological Association (APA)
Al-quhali, Ali Mohammed& Sun, Yu& Bai, Xizhuang& Jin, Zhe& Yu, Guibo. 2015. Surgical Modification of the Murine Calvaria Osteolysis Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056781
Modern Language Association (MLA)
Al-quhali, Ali Mohammed…[et al.]. Surgical Modification of the Murine Calvaria Osteolysis Model. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056781
American Medical Association (AMA)
Al-quhali, Ali Mohammed& Sun, Yu& Bai, Xizhuang& Jin, Zhe& Yu, Guibo. Surgical Modification of the Murine Calvaria Osteolysis Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056781