Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis
Joint Authors
Guan, Min
Zhao, Lu
Wang, Enfeng
Zhang, Xiaoqi
Karama, Sherif
Khundrakpam, Budhachandra
Zhang, Hongju
Wang, Meiyun
Cheng, Jingliang
Shi, Dapeng
Evans, Alan C.
Li, Yongli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The etiology and maintenance of insomnia are proposed to be associated with increased cognitive and physiological arousal caused by acute stressors and associated cognitive rumination.
A core feature of such hyperarousal theory of insomnia involves increased sensory processing that interferes with the onset and maintenance of sleep.
In this work, we collected structural magnetic resonance imaging data from 35 patients with primary insomnia and 35 normal sleepers and applied structural covariance analysis to investigate whether insomnia is associated with disruptions in structural brain networks centered at the sensory regions (primary visual, primary auditory, and olfactory cortex).
As expected, insomnia patients showed increased structural covariance in cortical thickness between sensory and motor regions.
We also observed trends of increased covariance between sensory regions and the default-mode network, and the salience network regions, and trends of decreased covariance between sensory regions and the frontoparietal working memory network regions, in insomnia patients.
The observed changes in structural covariance tended to correlated with poor sleep quality.
Our findings support previous functional neuroimaging studies and provide novel insights into variations in brain network configuration that may be involved in the pathophysiology of insomnia.
American Psychological Association (APA)
Zhao, Lu& Wang, Enfeng& Zhang, Xiaoqi& Karama, Sherif& Khundrakpam, Budhachandra& Zhang, Hongju…[et al.]. 2015. Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis. BioMed Research International،Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1056847
Modern Language Association (MLA)
Zhao, Lu…[et al.]. Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis. BioMed Research International No. 2015 (2015), pp.1-23.
https://search.emarefa.net/detail/BIM-1056847
American Medical Association (AMA)
Zhao, Lu& Wang, Enfeng& Zhang, Xiaoqi& Karama, Sherif& Khundrakpam, Budhachandra& Zhang, Hongju…[et al.]. Cortical Structural Connectivity Alterations in Primary Insomnia: Insights from MRI-Based Morphometric Correlation Analysis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-23.
https://search.emarefa.net/detail/BIM-1056847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056847