Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging
Joint Authors
Ribeiro, Helena M.
Corrêa, M. A.
Isaac, Vera Lucia Borges
Chiari-Andréo, Bruna Galdorfini
Marto, Joana Marques
Moraes, Jemima Daniela Dias
Leone, Beatriz Alves
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin.
Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products.
Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation.
In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid.
Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging.
The rheological and mechanical behavior and the in vitro release profile were assayed.
The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA.
American Psychological Association (APA)
Isaac, Vera Lucia Borges& Chiari-Andréo, Bruna Galdorfini& Marto, Joana Marques& Moraes, Jemima Daniela Dias& Leone, Beatriz Alves& Corrêa, M. A.…[et al.]. 2015. Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056852
Modern Language Association (MLA)
Isaac, Vera Lucia Borges…[et al.]. Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056852
American Medical Association (AMA)
Isaac, Vera Lucia Borges& Chiari-Andréo, Bruna Galdorfini& Marto, Joana Marques& Moraes, Jemima Daniela Dias& Leone, Beatriz Alves& Corrêa, M. A.…[et al.]. Rheology as a Tool to Predict the Release of Alpha-Lipoic Acid from Emulsions Used for the Prevention of Skin Aging. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056852