Module Based Differential Coexpression Analysis Method for Type 2 Diabetes
Joint Authors
Zheng, Chun-Hou
Huang, De-Shuang
Yuan, Lin
Xia, Junfeng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
More and more studies have shown that many complex diseases are contributed jointly by alterations of numerous genes.
Genes often coordinate together as a functional biological pathway or network and are highly correlated.
Differential coexpression analysis, as a more comprehensive technique to the differential expression analysis, was raised to research gene regulatory networks and biological pathways of phenotypic changes through measuring gene correlation changes between disease and normal conditions.
In this paper, we propose a gene differential coexpression analysis algorithm in the level of gene sets and apply the algorithm to a publicly available type 2 diabetes (T2D) expression dataset.
Firstly, we calculate coexpression biweight midcorrelation coefficients between all gene pairs.
Then, we select informative correlation pairs using the “differential coexpression threshold” strategy.
Finally, we identify the differential coexpression gene modules using maximum clique concept and k-clique algorithm.
We apply the proposed differential coexpression analysis method on simulated data and T2D data.
Two differential coexpression gene modules about T2D were detected, which should be useful for exploring the biological function of the related genes.
American Psychological Association (APA)
Yuan, Lin& Zheng, Chun-Hou& Xia, Junfeng& Huang, De-Shuang. 2015. Module Based Differential Coexpression Analysis Method for Type 2 Diabetes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056936
Modern Language Association (MLA)
Yuan, Lin…[et al.]. Module Based Differential Coexpression Analysis Method for Type 2 Diabetes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056936
American Medical Association (AMA)
Yuan, Lin& Zheng, Chun-Hou& Xia, Junfeng& Huang, De-Shuang. Module Based Differential Coexpression Analysis Method for Type 2 Diabetes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056936