Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals
Joint Authors
Cordeiro, A.
Pereira, S. E.
Saboya, C. J.
Ramalho, A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Obesity is represented mainly by abdominal obesity and insulin resistance (IR), both present in most individuals diagnosed with metabolic syndrome (MS).
IR is the key risk factor in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).
Objective.
To relate NAFLD to MS in class III obese individuals.
Methodology.
A descriptive cross-sectional study with class III obese individuals, aged ≥ 20–60 years.
Blood pressure measurement, weight, height, body mass index (BMI), waist circumference (WC) and blood glucose, insulin, high-density lipoprotein cholesterol (HDL-c), and triglycerides data were obtained.
HOMA-IR (homeostatic model assessment insulin resistance) calculation was carried out with a cutoff value of 2.71 for IR evaluation.
The diagnosis of NAFLD was performed by liver biopsy and the diagnosis of MS was performed in accordance with the National Cholesterol Education Program/Adult Treatment Panel III (NCEPATP III).
Results.
Of the 50 individuals evaluated, 86% were women and BMI means were 45.4 ± 3.6 Kg/m2.
The overall individuals had NAFLD, 70% steatosis, and 30% steatohepatitis.
The diagnosis of MS occurred in 56% but showed no significant association with NAFLD (P=0.254).
Triglycerides (178 ± 65.5 mg/dL) and insulin (28.2 ± 22.6 mcU/mL) mean values were significantly higher in steatohepatitis (P=0.002 and P=0.042, resp.) compared to individuals with steatosis.
IR was confirmed in 76% and showed a relationship with NAFLD severity.
Conclusion.
NAFLD was not related to MS; however, MS components, evaluated in isolation, as well as IR, were related to the presence and severity of NAFLD.
American Psychological Association (APA)
Cordeiro, A.& Pereira, S. E.& Saboya, C. J.& Ramalho, A.. 2015. Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056946
Modern Language Association (MLA)
Cordeiro, A.…[et al.]. Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056946
American Medical Association (AMA)
Cordeiro, A.& Pereira, S. E.& Saboya, C. J.& Ramalho, A.. Nonalcoholic Fatty Liver Disease Relationship with Metabolic Syndrome in Class III Obesity Individuals. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056946