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Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs
Joint Authors
Abdul Qadir, Muhammad
Ahmed, Mahmood
Iqbal, Muhammad
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Novel sulfonamides were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR).
In vitro, developed compounds were screened for their antibacterial activities against medically important gram (+) and gram (−) bacterial strains, namely, S.
aureus, B.
subtilis, E.
coli, and K.
pneumoniae.
The antibacterial activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm).
Among the tested compounds, it was found that compounds 5a and 9a have most potent activity against E.
coli with zone of inhibition: 31±0.12 mm (MIC: 7.81 μg/mL) and 30±0.12 mm (MIC: 7.81 μg/mL), respectively, nearly as active as ciprofloxacin (zone of inhibition: 32±0.12 mm).
In contrast, all the compounds were totally inactive against the gram (+) B.
subtilis.
American Psychological Association (APA)
Abdul Qadir, Muhammad& Ahmed, Mahmood& Iqbal, Muhammad. 2015. Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057307
Modern Language Association (MLA)
Abdul Qadir, Muhammad…[et al.]. Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057307
American Medical Association (AMA)
Abdul Qadir, Muhammad& Ahmed, Mahmood& Iqbal, Muhammad. Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057307