The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep
Joint Authors
Szalay, Gabor
Heiss, Christian
Schnettler, Reinhard
Lips, Katrin Susanne
Thormann, Ulrich
Alt, Volker
Heimann, Lydia
Gasquere, Cyrille
Franke, Jörg
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA).
However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism.
The aim of this pilot study was to evaluate the biocompatibility of an interference screw for ligament reconstruction made of magnesium alloy W4 by diecasting and milling and using different PEO-coatings with calcium phosphates.
PLLA and titanium screws were used as control samples.
The screws were implanted in the femur condyle of the hind leg of a merino sheep.
The observation period was six and twelve weeks and one year.
Histomorphometric, immunohistochemical, immunofluorescence, and molecular biological evaluation were conducted.
Further TEM analysis was done.
In all magnesium screws a clinically relevant gas formation in the vicinity of the biomaterial was observed.
Except for the PLLA and titanium control samples, no screw was fully integrated in the surrounding bone tissue.
Regarding the fabrication process, milling seems to produce less gas liberation and has a better influence on bone metabolism than diecasting.
Coating by PEO with calcium phosphates could not reduce the initial gas liberation but rather reduced the bone metabolism in the vicinity of the biomaterial.
American Psychological Association (APA)
Thormann, Ulrich& Alt, Volker& Heimann, Lydia& Gasquere, Cyrille& Heiss, Christian& Szalay, Gabor…[et al.]. 2015. The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057332
Modern Language Association (MLA)
Thormann, Ulrich…[et al.]. The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057332
American Medical Association (AMA)
Thormann, Ulrich& Alt, Volker& Heimann, Lydia& Gasquere, Cyrille& Heiss, Christian& Szalay, Gabor…[et al.]. The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057332