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A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays
Joint Authors
Regalia, Giulia
Biffi, Emilia
Ferrigno, G.
Pedrocchi, A.
Source
Computational Intelligence and Neuroscience
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The collection of good quality extracellular neuronal spikes from neuronal cultures coupled to Microelectrode Arrays (MEAs) is a binding requirement to gather reliable data.
Due to physical constraints, low power requirement, or the need of customizability, commercial recording platforms are not fully adequate for the development of experimental setups integrating MEA technology with other equipment needed to perform experiments under climate controlled conditions, like environmental chambers or cell culture incubators.
To address this issue, we developed a custom MEA interfacing system featuring low noise, low power, and the capability to be readily integrated inside an incubator-like environment.
Two stages, a preamplifier and a filter amplifier, were designed, implemented on printed circuit boards, and tested.
The system is characterized by a low input-referred noise (<1 μV RMS), a high channel separation (>70 dB), and signal-to-noise ratio values of neuronal recordings comparable to those obtained with the benchmark commercial MEA system.
In addition, the system was successfully integrated with an environmental MEA chamber, without harming cell cultures during experiments and without being damaged by the high humidity level.
The devised system is of practical value in the development of in vitro platforms to study temporally extended neuronal network dynamics by means of MEAs.
American Psychological Association (APA)
Regalia, Giulia& Biffi, Emilia& Ferrigno, G.& Pedrocchi, A.. 2015. A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays. Computational Intelligence and Neuroscience،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057668
Modern Language Association (MLA)
Regalia, Giulia…[et al.]. A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays. Computational Intelligence and Neuroscience No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1057668
American Medical Association (AMA)
Regalia, Giulia& Biffi, Emilia& Ferrigno, G.& Pedrocchi, A.. A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays. Computational Intelligence and Neuroscience. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1057668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057668