Finding Top- k Covering Irreducible Contrast Sequence Rules for Disease Diagnosis
Joint Authors
Sheng, Gang
Zhao, Yuhai
Li, Yuan
Yin, Ying
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diagnostic genes are usually used to distinguish different disease phenotypes.
Most existing methods for diagnostic genes finding are based on either the individual or combinatorial discriminative power of gene(s).
However, they both ignore the common expression trends among genes.
In this paper, we devise a novel sequence rule, namely, top- k irreducible covering contrast sequence rules (Top k IRs for short), which helps to build a sample classifier of high accuracy.
Furthermore, we propose an algorithm called MineTop k IRs to efficiently discover Top k IRs.
Extensive experiments conducted on synthetic and real datasets show that MineTop k IRs is significantly faster than the previous methods and is of a higher classification accuracy.
Additionally, many diagnostic genes discovered provide a new insight into disease diagnosis.
American Psychological Association (APA)
Zhao, Yuhai& Li, Yuan& Yin, Ying& Sheng, Gang. 2015. Finding Top- k Covering Irreducible Contrast Sequence Rules for Disease Diagnosis. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057872
Modern Language Association (MLA)
Zhao, Yuhai…[et al.]. Finding Top- k Covering Irreducible Contrast Sequence Rules for Disease Diagnosis. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057872
American Medical Association (AMA)
Zhao, Yuhai& Li, Yuan& Yin, Ying& Sheng, Gang. Finding Top- k Covering Irreducible Contrast Sequence Rules for Disease Diagnosis. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057872