An Adaptive Thresholding Method for BTV Estimation Incorporating PET Reconstruction Parameters: A Multicenter Study of the Robustness and the Reliability
Joint Authors
Botta, F.
Fioroni, F.
Grassi, E.
Pacilio, M.
Cremonesi, M.
Brambilla, M.
Matheoud, R.
Basile, C.
Bracco, C.
Cavedon, C.
Morzenti, S.
Giri, M.
Gallivanone, F.
De Ponti, E.
Stasi, M.
Pasetto, S.
Valzano, S.
Zanni, D.
Castiglioni, Isabella
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
The aim of this work was to assess robustness and reliability of an adaptive thresholding algorithm for the biological target volume estimation incorporating reconstruction parameters.
Method.
In a multicenter study, a phantom with spheres of different diameters (6.5–57.4 mm) was filled with 18F-FDG at different target-to-background ratios (TBR: 2.5–70) and scanned for different acquisition periods (2–5 min).
Image reconstruction algorithms were used varying number of iterations and postreconstruction transaxial smoothing.
Optimal thresholds (TS) for volume estimation were determined as percentage of the maximum intensity in the cross section area of the spheres.
Multiple regression techniques were used to identify relevant predictors of TS.
Results.
The goodness of the model fit was high (R2: 0.74–0.92).
TBR was the most significant predictor of TS.
For all scanners, except the Gemini scanners, FWHM was an independent predictor of TS.
Significant differences were observed between scanners of different models, but not between different scanners of the same model.
The shrinkage on cross validation was small and indicative of excellent reliability of model estimation.
Conclusions.
Incorporation of postreconstruction filtering FWHM in an adaptive thresholding algorithm for the BTV estimation allows obtaining a robust and reliable method to be applied to a variety of different scanners, without scanner-specific individual calibration.
American Psychological Association (APA)
Brambilla, M.& Matheoud, R.& Basile, C.& Bracco, C.& Castiglioni, Isabella& Cavedon, C.…[et al.]. 2015. An Adaptive Thresholding Method for BTV Estimation Incorporating PET Reconstruction Parameters: A Multicenter Study of the Robustness and the Reliability. Computational and Mathematical Methods in Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057938
Modern Language Association (MLA)
Brambilla, M.…[et al.]. An Adaptive Thresholding Method for BTV Estimation Incorporating PET Reconstruction Parameters: A Multicenter Study of the Robustness and the Reliability. Computational and Mathematical Methods in Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057938
American Medical Association (AMA)
Brambilla, M.& Matheoud, R.& Basile, C.& Bracco, C.& Castiglioni, Isabella& Cavedon, C.…[et al.]. An Adaptive Thresholding Method for BTV Estimation Incorporating PET Reconstruction Parameters: A Multicenter Study of the Robustness and the Reliability. Computational and Mathematical Methods in Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057938