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Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson’s Syndrome: A Case Report and Review of the Literature
Joint Authors
Kurowska, Maria
Nowakowski, Andrzej
Zieliński, Grzegorz
Malicka, Joanna
Tarach, Jerzy S.
Maksymowicz, Maria
Denew, Piotr
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Invasive tumours in Nelson’s syndrome need aggressive therapy.
Recent reports have documented the efficacy of temozolomide (TMZ) in the treatment of adenomas resistant to conventional management.
Objective.
The review of the literature concerning TMZ treatment of atypical corticotroph adenomas and a case study of 56-year-old woman who developed Nelson’s syndrome.
Treatment Proceeding.
The patient with Cushing’s disease underwent transsphenoidal adenomectomy followed by a 27-month-long period of remission.
Due to a regrowth of the tumor, she underwent two reoperations followed by stereotactic radiotherapy.
Because of treatment failures, bilateral adrenalectomy was performed.
Then she developed Nelson’s syndrome.
A fourth transsphenoidal adenomectomy was performed, but there was a rapid recurrence.
Five months later, she underwent a right frontotemporal craniotomy.
Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time.
Only TMZ therapy resulted in marked clinical, biochemical, and radiological improvement.
To date, this is the first case of invasive corticotroph adenoma in Nelson’s syndrome treated with temozolomide in Poland.
Conclusion.
In our opinion, temozolomide can be an effective treatment option of invasive adenomas in Nelson’s syndrome.
American Psychological Association (APA)
Kurowska, Maria& Nowakowski, Andrzej& Zieliński, Grzegorz& Malicka, Joanna& Tarach, Jerzy S.& Maksymowicz, Maria…[et al.]. 2015. Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson’s Syndrome: A Case Report and Review of the Literature. Case Reports in Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1058409
Modern Language Association (MLA)
Kurowska, Maria…[et al.]. Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson’s Syndrome: A Case Report and Review of the Literature. Case Reports in Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1058409
American Medical Association (AMA)
Kurowska, Maria& Nowakowski, Andrzej& Zieliński, Grzegorz& Malicka, Joanna& Tarach, Jerzy S.& Maksymowicz, Maria…[et al.]. Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson’s Syndrome: A Case Report and Review of the Literature. Case Reports in Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1058409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058409