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Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine A
Joint Authors
Takahashi, Tohru
Maruyama, Yumiko
Saitoh, Mayuko
Itoh, Hideto
Yoshimoto, Mitsuru
Tsujisaki, Masayuki
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Epstein-Barr virus (EBV) associated lymphoproliferative disorder (LPD) after immunosuppressive therapy for aplastic anemia (AA) is extremely rare in a nontransplant setting and has not been well described.
This report describes a severe AA patient in whom fatal EBV-LPD developed after being treated with rabbit antithymocyte globulins (ATG) and cyclosporine A (CsA).
An 81-year-old man was diagnosed as having severe AA.
He was started on CsA followed by administration of ATG for five consecutive days.
One month after the start of ATG, persistent fever which was not responsive to antibiotics or antifungal agents developed and atypical lymphocytes emerged in peripheral blood.
Repeated blood cultures were negative.
An extremely high level of EBV virus in his peripheral blood plasma was detected by means of a quantitative real-time PCR assay.
Even after the cessation of CsA, the fever persisted and the peripheral atypical lymphocytes proliferated rapidly.
The patient suffered from respiratory failure, liver dysfunction, and metabolic acidosis.
Rituximab was administered without success and he died.
American Psychological Association (APA)
Takahashi, Tohru& Maruyama, Yumiko& Saitoh, Mayuko& Itoh, Hideto& Yoshimoto, Mitsuru& Tsujisaki, Masayuki. 2015. Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine A. Case Reports in Hematology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058650
Modern Language Association (MLA)
Takahashi, Tohru…[et al.]. Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine A. Case Reports in Hematology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058650
American Medical Association (AMA)
Takahashi, Tohru& Maruyama, Yumiko& Saitoh, Mayuko& Itoh, Hideto& Yoshimoto, Mitsuru& Tsujisaki, Masayuki. Fatal Epstein-Barr Virus Reactivation in an Acquired Aplastic Anemia Patient Treated with Rabbit Antithymocyte Globulin and Cyclosporine A. Case Reports in Hematology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058650