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Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy
Joint Authors
Singh, Amandeep
Zaeri, Nayere
Ho, Immanuel K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Patients treated with interferon (IFN) based therapies may develop exacerbation of autoimmune disease.
We herein present the case of a 53-year-old female patient who developed celiac disease (CD) as a result of triple therapy (interferon, ribavirin, and boceprevir) for chronic HCV.
Case.
53-year-old Caucasian female with past medical history of IV drug abuse was referred for abnormal LFTs.
Laboratory data showed HCV RNA of 4,515,392 IU/mL, HCV genotype 1a, with normal LFTs.
She was treated with 4 weeks of pegylated interferon alfa-2a plus ribavirin, followed by triple therapy using boceprevir for a total of 28 weeks.
Approximately 4 weeks after initiation of triple therapy patient developed loose nonbloody bowel movements and was also found to have anemia.
Biopsies from first and second portions of the duodenum were consistent with CD.
The patient was treated with a gluten-free diet.
Her intestinal symptoms improved and the hemoglobin returned to normal.
Conclusion.
Chronic HCV patients being treated with interferon alfa can develop celiac disease during or after therapy.
For patients with positive autoantibodies, all-oral-IFN-free regimens should be considered.
Celiac disease should be considered in patients who develop CD-like symptoms while on and shortly after cessation of interferon alfa therapy.
American Psychological Association (APA)
Singh, Amandeep& Zaeri, Nayere& Ho, Immanuel K.. 2015. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058665
Modern Language Association (MLA)
Singh, Amandeep…[et al.]. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058665
American Medical Association (AMA)
Singh, Amandeep& Zaeri, Nayere& Ho, Immanuel K.. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy. Case Reports in Hepatology. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058665