Obstructive Jaundice as Initial Presentation of Multiple Myeloma: Case Presentation and Literature Review
Joint Authors
Khan, Yasir
Mansour, Iyad
Ong, Eric
Shrestha, Manish
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Multiple myeloma is a malignant plasma-cell disorder that primarily involves the bone marrow, but extramedullary involvement is becoming increasingly common (Bladé et al., 2012) both at initial presentation and follow-up.
Most common initial presentations for multiple myeloma include generalized fatigue, renal insufficiency, bone pain, and recurrent bacterial infections.
We present a case of a healthy 55-year-old man that presented to the emergency department with a three-week history of anorexia and jaundice without any past medical history.
Patient’s initial labs were significant for hyperbilirubinemia and elevated liver function enzymes (AST, ALT, ALP, and GGT).
Additional laboratory workup was significant for mild hypercalcemia and increased protein gap.
MRI and ERCP suggested primary sclerosing cholangitis but were not diagnostic.
Liver biopsy illustrated plasma-cell infiltration and bone marrow biopsy diagnosed multiple myeloma with extramedullary disease.
Patient was started on dexamethasone, bortezomib, and cyclophosphamide, but, despite this aggressive regimen, the patient continued to decline.
We take this opportunity to present this atypical presentation of a common hematological malignancy and review the associated literature.
American Psychological Association (APA)
Khan, Yasir& Mansour, Iyad& Ong, Eric& Shrestha, Manish. 2015. Obstructive Jaundice as Initial Presentation of Multiple Myeloma: Case Presentation and Literature Review. Case Reports in Medicine،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058888
Modern Language Association (MLA)
Khan, Yasir…[et al.]. Obstructive Jaundice as Initial Presentation of Multiple Myeloma: Case Presentation and Literature Review. Case Reports in Medicine No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1058888
American Medical Association (AMA)
Khan, Yasir& Mansour, Iyad& Ong, Eric& Shrestha, Manish. Obstructive Jaundice as Initial Presentation of Multiple Myeloma: Case Presentation and Literature Review. Case Reports in Medicine. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1058888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058888