Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis
Joint Authors
Giannas, Raphael
Kanellou, Anna
Anagnostopoulos, Nikolaos
Pagoni, Stamata
Voulgari, Christina
Paterakis, Georgios
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Clozapine is a second-generation antipsychotic agent from the benzodiazepine group indicated for treatment-resistant schizophrenia and other psychotic conditions.
Using clozapine earlier on once a case appears to be refractory limits both social and personal morbidity of chronic psychosis.
However treatment with second-generation antipsychotics is often complicated by adverse effects.
We present a case of a 33-year-old Caucasian woman with a 25-year history of refractory psychotic mania after switching to a 2-year clozapine therapy.
She presented clozapine-induced absolute neutropenia, agranulocytosis, which were complicated by Streptococcus pneumonia and sepsis.
Clozapine-induced thromboembolism of the common femoral and right proximal iliac vein, as well as allergic vasculitis, was diagnosed.
She achieved full remission on granulocyte-colony stimulating factor and specific antibiotic treatment.
Early detection of severe clozapine-induced absolute neutropenia and agranulocytosis enabled the effective treatment of two among its most severe complications.
Additional evidence to the previously reported possible causal relation between clozapine and venous thromboembolism is offered.
Finally, clozapine-induced allergic vasculitis is confirmed as a late adverse effect of clozapine therapy.
American Psychological Association (APA)
Voulgari, Christina& Giannas, Raphael& Paterakis, Georgios& Kanellou, Anna& Anagnostopoulos, Nikolaos& Pagoni, Stamata. 2015. Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis. Case Reports in Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1058892
Modern Language Association (MLA)
Voulgari, Christina…[et al.]. Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis. Case Reports in Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1058892
American Medical Association (AMA)
Voulgari, Christina& Giannas, Raphael& Paterakis, Georgios& Kanellou, Anna& Anagnostopoulos, Nikolaos& Pagoni, Stamata. Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis. Case Reports in Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1058892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1058892