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Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome
Joint Authors
Bingeliene, Arina
Shapiro, Colin M.
Chung, Sharon A.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Prader-Willi syndrome (PWS) is a genetic disorder characterized by short stature, mental retardation, hypotonia, functionally deficient gonads, and uncontrolled appetite leading to extreme obesity at an early age.
Patients with this condition require multidisciplinary medical care, which facilitates a significant improvement in quality of life.
PWS is the first human disorder to be attributed to genomic imprinting.
Prevalence varies in the literature, ranging from 1 in 8,000 in the Swedish population to 1 in 54,000 in the United Kingdom.
Rarely, the genetic mechanism responsible for Prader-Willi syndrome can be inherited.
We report a highly unique case of three siblings who share this condition.
This report describes a case of two brothers and one half sister with PWS.
All three siblings have sleep-related complaints.
The sister died at the age of 24 years in her sleep, with the cause of death reported as obstructive sleep apnea.
The outcome was positive in both of the brothers’ cases as a result of professional medical care and specific tailored recommendations implemented by their mother.
A review of the relevant literature vis-à-vis sleep and PWS is provided.
American Psychological Association (APA)
Bingeliene, Arina& Shapiro, Colin M.& Chung, Sharon A.. 2015. Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome. Case Reports in Neurological Medicine،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059008
Modern Language Association (MLA)
Bingeliene, Arina…[et al.]. Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome. Case Reports in Neurological Medicine No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1059008
American Medical Association (AMA)
Bingeliene, Arina& Shapiro, Colin M.& Chung, Sharon A.. Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome. Case Reports in Neurological Medicine. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1059008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1059008