Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease
Joint Authors
Fu, Xiaojie
Wang, Jianping
Li, Nan
Ma, Jun
Gu, Zhiqiang
Jiang, Chao
Yu, Lie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cistanches Herba (CH) is thought to be a “Yang-invigorating” material in traditional Chinese medicine.
We evaluated neuroprotective effects of Cistanches Herba on Alzheimer’s disease (AD) patients.
Moderate AD participants were divided into 3 groups: Cistanches Herba capsule (CH, n = 10 ), Donepezil tablet (DON, n = 8 ), and control group without treatment n = 6 .
We assessed efficacy by MMSE and ADAS-cog, and investigated the volume changes of hippocampus by 1.5 T MRI scans.
Protein, mRNA levels, and secretions of total-tau (T-tau), tumor necrosis factor-α (TNF-α), and interleukin- (IL) 1β (IL-1β) in cerebrospinal fluid (CSF) were detected by Western blot, RT-PCR, and ELISA.
The scores showed statistical difference after 48 weeks of treatment compared to control group.
Meanwhile, volume changes of hippocampus were slight in drug treatment groups but distinct in control group; the levels of T-tau, TNF-α, and IL-1β were decreased compared to those in control group.
Cistanches Herba could improve cognitive and independent living ability of moderate AD patients, slow down volume changes of hippocampus, and reduce the levels of T-tau, TNF-α, and IL-1β.
It suggested that Cistanches Herba had potential neuroprotective effects for moderate AD.
American Psychological Association (APA)
Li, Nan& Wang, Jianping& Ma, Jun& Gu, Zhiqiang& Jiang, Chao& Yu, Lie…[et al.]. 2015. Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061142
Modern Language Association (MLA)
Li, Nan…[et al.]. Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1061142
American Medical Association (AMA)
Li, Nan& Wang, Jianping& Ma, Jun& Gu, Zhiqiang& Jiang, Chao& Yu, Lie…[et al.]. Neuroprotective Effects of Cistanches Herba Therapy on Patients with Moderate Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1061142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1061142